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As you grow older, age-related stiffness and discom­fort in the joints becomes a fact of life. Activities once routine become a challenge as limited mobility hampers your every move. AprèsFlex represents a quantum leap forward in the delivery to aging joints of boswellia, long prized for its ability to help with inflammatory issues. It is a superior inhibitor of the enzyme 5-lipoxygenase or 5-LOX. Excess activity of 5-LOX results in the accumulation of leukotriene B4, a pro-inflammatory compound that affects aging joints. Boswellia has been shown to bind directly to the 5-LOX enzyme, preventing it from facilitating production of pro-inflammatory leukotrienes. Inflammatory reactions are regulated by a series of cytokines produced in the body. Normal aging results in an unfavorable balance of these cytokines that contributes to persistent inflammatory conditions. Studies have shown that a special fraction found in black tea suppresses proinflammatory cytokines at the genomic level. Scientists have found that these com­pounds called theaflavins uniquely downregulate the expression of genes associated with inflammatory cytokines. This ArthroMax with Theaflavins formulation provides bioactive theaflavin fractions, along with MSM (methylsulfonylmethane), which contains sulfur components that are critically important in maintain­ing comfortable joint function. It also contains FruiteX B OsteoBoron, a patented form of boron identical to natural plant forms found in food. Considered more bioavail­able than other forms of boron, FruiteX B OsteoBoron supports healthy bones and joints. AprèsFlex represents a quantum leap forward in the delivery to aging joints of boswellia, long prized for its ability to help with inflammatory issues. It is a superior inhibitor of the enzyme 5-lipoxygenase or 5-LOX.

Artichoke Leaf Extract is made from the long, serrated basal leaves of the plant, which contains the highest concentration of biologically active compounds. These compounds have demonstrated antioxidant action and the ability to maintain healthy digestion and liver function by promoting adequate bile flow.317-327 More findings show possible benefits for cardiovascular health, endothelial function and healthy cholesterol levels within normal limits.328-335 Bile serves as a major carrier of cholesterol and detoxified substances for excretion from the body.Artichoke Leaf Extract has been concentrated and standardized to ensure the highest quality, consistency, and biological activity.

Vitamin C, or ascorbic acid, is a white, crystalline, water-soluble substance found in citrus fruits. As an antioxidant, vitamin C scavenges free radicals in the body and protects tissues from oxidative stress. Vitamin C also promotes the absorption of iron, while preventing its oxidation. Vitamin C is a vital cofactor to the formation of collagen, the connective tissue that supports arterial walls, skin, bones, and teeth. More vitamin C is contained in the adrenal glands than any other organ in the body and is required at higher levels during times of stress. Physical stresses on the body such as ingestion of heavy metals, cigarette smoking, immune impairment, extreme temperatures, and chronic use of certain medications such as aspirin also signal the need for increased intake of vitamin C. Ascorbyl palmitate (AP) is an ester formed from ascorbic acid and palmitic acid creating a fat-soluble form of vitamin C that can reach tissue areas ascorbic acid cannot. This form is purely synthetic from two natural compounds; it has been shown to be beneficial for protecting the lipids from peroxidation. The lipophilic AP is able to cross biological barriers and satisfies the tissue demand for ascorbate better than the hydrophilic form. AP should be considered as the preferred form of transport of ascorbate into neural tissues. Technically, the ascorbic acid ?part? of ascorbyl palmitate is only 40% of the total weight. Since ascorbyl palmitate and ascorbic acid might work in separate areas of the body, the concentration of ascorbic acid by weight has little relevance to the benefits of ascorbyl palmitate, so it has not been included in the product contents description.

Astaxanthin is a fat-soluble compound. The challenge to deriving maximum benefits is its normally limited absorption?as low as about 50% . Assimilation of astaxanthin is impeded by limited uptake and intestinal degradation. Astaxanthin with Phospholipids combines 4 milligrams of natural astaxanthin with a proprietary blend of phospholipids. By incorporating phospholipids, scientific research shows that absorption may be enhanced several-fold. Astaxanthin with Phospholipids uses four different phospholipids to facilitate maximum absorption of astaxanthin into the bloodstream, where it is transported to cells throughout the body.

Benfotiamine, a fat-soluble form of vitamin B1 (thiamine), supports healthy blood sugar metabolism and helps protect the body?s tissues against advanced glycation end products and oxidative stress. For example, the enzyme transketolase is critical to blood sugar metabolism. Like many enzymes, transketolase requires a co-factor. In this case, it needs assistance from thiamine. Unfortunately, thiamine is water-soluble, which makes it less available to the interior of the cell. Benfotiamine is fat-soluble and can easily penetrate into the inside of cells. It is also more bioavailable than the water-soluble thiamine. In a landmark study, benfotiamine effectively increased transketolase activity in cell cultures by an astounding 300%, compared to a mere 20% for thiamine. This robust activation was sufficient to block three of the four major metabolic pathways leading to blood vessel damage. Benfotiamine also blocks the activation of the transcription factor known as nuclear factor-kappa B (NF-kB), which is implicated in numerous inflammatory conditions. Overall, benfotiamine can activate glucose metabolism and promote healthy blood glucose levels in those already within normal range. It can also reduce formation of advanced glycation end products to prevent glucose toxicity and correct endothelial cell defects caused by high concentrations of blood glucose, especially inside endothelial, retinal, kidney and nerve cells. Benfotiamine also helps maintain healthy endothelial function. Benfotiamine with Thiamine is a low-cost dietary supplement that can help maintain blood sugar levels in those already within normal range and support the health of the nerves, kidneys, eyes, blood vessels, and heart.

While thousands of published studies support the benefits of conventional antioxidants (like vitamins E and C), scientists have discovered that extracts from brightly colored fruits and vegetables possess far greater antioxidant capacity. In fact, human epidemiological studies show that those who regularly consume these potent plant-based anthocyanins and other polyphenols remain far healthier in their advanced years. If you?re not eating the recommended five servings of fruits and vegetables a day, especially the dark-skinned varieties, you could be lacking optimal antioxidant protection against toxic free radicals. To measure the antioxidant strengths of food and other substances, scientists use an ORAC score. A higher score means that a particular food is better at protecting the body?s cells from free radical-induced damage. But problems with availability, freshness and cost mean that obtaining a wide variety of high-ORAC fruits and vegetables daily can be difficult. So Life Extension developed the Berry Complete formula to provide a concentrated blend of fruit and vegetable extracts with some of the highest ORAC scores around. Each capsule is packed with scientifically proven polyphenols and anthocyanins from seasonal and perishable fruits and vegetables with the highest ORAC values. Just one capsule provides the antioxidant capacity of more than 50% of the daily recommended five-a-day intake of fruits and vegetables.

Beneficial bacteria reside in the intestinal tract and aid the digestive process, primarily by keeping harmful bacteria from growing out of control. These beneficial bacteria (also called probiotics) are thought to support immune function and gut health, increase the body?s resistance to infection, and prevent the onset of allergenic response. Probiotics literally means for life. Traditional diets (like the Mediterranean Diet) with foods that contain probiotics have been shown to promote health and longevity. Probiotics are thought to facilitate healthy GI and perform many other important functions. For example, researchers have discovered that probiotics help decrease nuclear factor kappa B (NFkB), a pro-inflammatory cytokine, and positively modulate cellular signaling pathways. Studies have also shown that probiotics can influence youthful gene expression. Properly formulated probiotics provide biologically active materials that can positively influence many aspects of human health. 70%-80% of immunoglobulin-producing cells reside in the gut which is populated by nearly 100 trillion microorganisms, many of which are beneficial bacteria. These bacteria are considered a living part of the human organism. With age, we can experience a decline in vital probiotics and the strength of the immune system. Restoring the gut?s friendly bacteria can stimulate and regulate healthy immune function. BB536, a unique well-studied strain of the bifidobacteria probiotic, increases the number of healthy bacteria in the colon. An in vivo study demonstrated a significant increase in longevity in mice supplemented with bifidobacteria. BB536 was also found to reduce production of inflammatory cytokines that often accompany seasonal symptom development. Each capsule of Bifido GI Balance provides two billion colony-forming units of viable healthy bacteria.

Tender, sensitive joints can limit everyday activities. As people age and continue to put stress on their joints, they can compromise joint cartilage which exposes small collagen fibers. The body?s immune system mistakenly identifies these collagen fibers as foreign cells. This triggers an inflammatory response against the collagen-containing cartilage in one's own joints. Inflammation and joint discomfort can soon follow. New data show that a patented collagen provides targeted support for the immune issues related to joint discomfort. Life Extension offers Bio-Collagen with Patented UC-II a novel form of undenatured type II collagen from chicken cartilage. Taken orally, UC-II travels to the intestinal tract where it "introduces" the immune system to the same type of collagen molecules found in joint cartilage. Not just any form of collagen will do. Normally, when chicken collagen is processed, its molecular shape is changed. It loses bioactivity and becomes denatured which researchers found has no beneficial effect2 on the immune system. Fortunately, a unique processing technique preserves the correct molecular shape of the collagen3,4 and preserves its bioactivity5 producing a form known as undenatured collagen. The result of this innovative process is an undenatured chicken collagen called Bio-Collagen with Patented UC-II. Scientific studies have found that UC-II reduced sensitive joint discomfort and eased joint function. One double-blind, placebo-controlled study on patients found that UC-II provided relief by 33%, and decreased joint discomfort scores by a remarkable 40% in just 90 days.

To help you deal with the stress and pressures of everyday life, Life Extension offers Bioactive Milk Peptides in standalone form, for daytime use to help with stress or before bedtime to support relaxation. Each capsule contains the same patented Lactium formula Europeans have used for years to help with sleep and stress-related issues. Bioactive Milk Peptides (Lactium) are a cutting-edge nutrient complex consisting of patented bioactive peptides found naturally in milk. Used widely in Europe to promote sustained and restful sleep patterns, published studies reveal that these bioactive milk peptides also promote relaxation, help with stress, and support daytime cognition. A group of 63 women reporting a variety of sleep-related difficulties experienced as much as 65.6% improvement in their symptoms with just 150 mg per day of these bioactive milk peptides. In another study, the same 150 mg dose induced substantial improvements across 27 markers of sleep quality and stress response in 165 healthy adults. And in a third study, a group of healthy men and women taking 150 mg per day of these bioactive milk peptides for one month experienced a 50% improvement in sleep quality after two weeks and needed 30% less time to fall asleep after 4 weeks.

Biotin is an unnumbered member of the water soluble B-complex family, normally only required in minute amounts. Biotin is used as a cofactor of enzymes involved in fatty acid metabolism, gluconeogenesis, and amino acid catabolism, and is essential in maintaining metabolic homeostasis. Biotin plays an important role in metabolic functioning as a coenzyme carrier of activated carbon dioxide in the TCA cycle (also known as the Krebs cycle). In its coenzyme form, biotin synthesizes glucose from non-carbohydrate sources, and synthesizes and breaks down certain fatty acids and amino acids.

As we age, a balanced immune and inflammatory response becomes critical to guarding our health. Research has shown Black Cumin Seed Oil to be particularly effective. Scientists have determined that black cumin seeds contain a broad spectrum of active compounds. Combined, these compounds provide powerful and wide-ranging immune support and promote healthy inflammatory response. A number of biological factors contribute to the body?s normal inflammatory activity, including cell-signaling chemicals and hormone-like messengers. In a series of scientific studies, Black Cumin Seed Oil has been shown to support the normal effectiveness of these inflammatory factors. Also, an aging, healthy immune system needs to orchestrate the activity of macrophages and helper T-cells. Black Cumin Seed Oil was also shown to support the optimal function of these vitally important defensive activities. By acting on both immune factors and inflammatory factors, Black Cumin Seed Oil supports a healthy immune system?which is increasingly important as we age?and facilitates a healthy inflammatory response .

As we age, a balanced immune and inflammatory response becomes critical to guarding our health. Research has shown Black Cumin Seed Oil to be particularly effective. Scientists have determined that black cumin seeds contain a broad spectrum of active compounds. Combined, these compounds provide powerful and wide-ranging immune support and promote healthy inflammatory response. A number of biological factors contribute to the body?s normal inflammatory activity, including cell-signaling chemicals and hormone-like messengers. In a series of scientific studies, Black Cumin Seed Oil has been shown to support the normal effectiveness of these inflammatory factors. Also, an aging, healthy immune system needs to orchestrate the activity of macrophages and helper T-cells. Black Cumin Seed Oil was also shown to support the optimal function of these vitally important defensive activities. By acting on both immune factors and inflammatory factors, Black Cumin Seed Oil supports a healthy immune system?which is increasingly important as we age?and facilitates a healthy inflammatory response . Since curcumin possesses some of the properties of black cumin seed oil, some people might want to take both nutrients in the same capsule.

The two most active constituents found in blueberries are anthocyanins and pterostilbene. Blueberry anthocyanins are considered one of nature?s most potent antioxidants. Pterostilbene is the other blueberry constituent that helps maintain healthy lipid and glucose levels that are already within healthy ranges. Through its unique biological effects and antioxidative potential, pterostilbene helps maintain healthy DNA structure. Scientists have discovered mechanisms to explain how blueberries can improve memory and restore healthy neuronal function to aged brains. Blueberry Extract Capsules contain a combination of highly concentrated wild blueberry extracts (not cultivated). These extracts are standardized to natural compounds that have the highest health benefits associated with consumption of fresh blueberries. To augment the benefits of this healthful fruit, a new wild blueberry extract has been added to Blueberry Extract that provides more potent active ingredients than cultivated blueberries. Blueberry Extract contains AuroraBlue wild Alaskan blueberries, which possess nearly 10 times the antioxidant capacity of cultivated berries.

When scientists analyze fruits and vegetables for their antioxidant capability, blueberries rank among the highest in their capacity to destroy free radicals. Rich in antioxidants that combat oxidative stress and inflammation, blueberry extracts not only help preserve youthful cognitive function, but also help maintain healthy blood flow via several mechanisms, including maintaining already normal LDL levels and blood pressure within normal limits and pre-serving endothelial and vascular function. The two most active constituents found in blueberries are anthocyanins and pterostilbene. Blueberry anthocyanins are considered one of nature?s most potent antioxidants. Pterostilbene is the other blueberry constituent that helps maintain healthy lipid and glucose levels that are already within healthy ranges. Through its unique biological effects and antioxidative potential, pterostilbene helps maintain healthy DNA structure. To augment the benefits of this healthful fruit, a new wild blueberry extract has been added to Blueberry Extract with Pomegranate that provides more potent active ingredients than cultivated blueberries. Blueberry Extract with Pomegranate contains AuroraBlue , which is made from wild Alaskan blueberries that grow in a completely natural environment without exposure to any chemicals. This complex of wild fruits belonging to the genus Vaccinium is rich in unique antioxidants (anthocyanins and pterostilbene being the two most active) and possesses nearly 10 times the antioxidant capacity of cultivated berries. Blueberry Extract with Pomegranate contains potent doses of pomegranate extract in just one capsule. Pomegranate fruit contains polyphenols, tannins, and anthocyanins - all beneficial antioxidants. Compounds known as punicalagins ?also found in pomegranate benefit arterial health by virtue of their ability to regulate healthy endothelial function.

Throughout life, cells known as osteoblasts construct bone matrix and fill it with calcium. At the same time, osteoclasts work just as busily to tear down and resorb bone. This fine balance is regulated by many factors, including systemic hormones and cytokines. Bone mass reaches its peak by the middle of the third decade of life and plateaus for about ten years, during which time bone turnover is constant, with bone formation approximately equaling bone resorption. As our bodies age, this fine balance is lost. As the relative hormone levels shift in midlife - more drastically in women than in men - the osteoclasts gain the upper hand and bone mass begins to dwindle. Some bone is already being lost by the time women reach menopause, but the rate of loss can increase up to tenfold during the first five years after menopause. Bone density loss is not just associated with calcium deficiency, but also with an insufficient intake of a host of other nutrients including magnesium and vitamin D3 . In order for calcium to help maintain healthy bones, adequate amounts of vitamin D3, zinc, magnesium, manganese, and other nutrients should be available so that calcium and phosphorus can be incorporated into the bone matrix. Additionally, many forms of calcium are not particularly well absorbed. Calcium is the most abundant mineral in the body ... primarily found in the bones and teeth. In bone formation, calcium forms crystals that provide strength to maturing bone. Peak bone mass is usually achieved when people are in their 20s. While loss of bone mineral density is more commonly experienced by women, aging men can also have this issue. Both men and women may experience significant deficits of magnesium if they do not supplement. Bone Restore now contains magnesium citrate, which is one of the most absorbable forms of magnesium. Magnesium is not only needed to maintain strong bones, but it is critical to promoting a healthy vascular system. In fact, magnesium is critical for facilitating hundreds of enzymatic reactions that our bodies require to maintain optimal health. To overcome the impediments that preclude aging adults from achieving optimal calcium status, Life Extension offers a proprietary comprehensive mineral formula called Bone Restore which has been designed to support healthy bone density and strength. Bone Restore provides 1200 milligrams of elemental calcium from three different forms, along with the critically important nutrients magnesium, boron, zinc, silicon, manganese and vitamin D3 needed for healthy bones. In fact, the boron in this formula, called FruiteX B OsteoBoron , is a boron/carbohydrate complex, similar to what is found in fruits and vegetables and is more bioavailable than boron citrate. Scientific research has established the beneficial effects of boron on the strength of bones and joints. One reason why aging people experience bone mineral density loss even though they are taking calcium supplements is that they may not be ab