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Vitamin D3 can be synthesized by humans in the skin upon exposure to ultraviolet-B (UVB) radiation from sunlight. But, due to the winter season, weather conditions, and sun screen usage, the body?s ability to produce optimal vitamin D levels may be inhibited. These factors point to the value of taking a daily vitamin D supplement. Vitamin D has long provided significant support for healthy bone density. However, scientists have also validated the critical role that vitamin D plays in regulating healthy cell division and differentiation, and its profound effects on human immunity. These findings link a deficiency of vitamin D to a host of common age-related problems. As a result of evidence of widespread vitamin D deficiency, prominent nutritional scientists are calling on Americans to increase their vitamin D intake to 1,000 IU per day and higher. Life Extension recommends that healthy adults supplement each day with at least 2,000 IU of vitamin D. Elderly adults may benefit from higher doses such as 5,000 IU daily up to 10,000 IU daily. The objective of taking a vitamin D supplement is to achieve an optimal 25-hydroxy vitamin D blood level of 50 ng/mL (and higher). Vitamin D in the amount of 2,000 IU is contained in the multinutrient Life Extension Mix and the multivitamin Two-Per-Day Tablets. A vitamin D blood test (available online or by calling the Life Extension Blood Lab at 1-800-208-3444), can help you determine the additional amount of vitamin D you may need to supplement to achieve an optimal level. For those already obtaining 1,000-3,000 IU of vitamin D in their multinutrient formulas, this 5,000 IU potency is what many need to achieve optimal vitamin D blood levels. Life Extension has upgraded its vitamin D capsules to a small, easy to swallow softgel form that does not include allergen ingredients or vegetable stearate.

Vitamin D3 can be synthesized by humans in the skin upon exposure to ultraviolet-B (UVB) radiation from sunlight. But, due to the winter season, weather conditions, and sun screen usage, the body?s ability to produce optimal vitamin D levels may be inhibited. These factors point to the value of taking a daily vitamin D supplement. Vitamin D has long provided significant support for healthy bone density. However, scientists have also validated the critical role that vitamin D plays in regulating healthy cell division and differentiation, and its profound effects on human immunity. These findings link a deficiency of vitamin D to a host of common age-related problems. The current RDA is only 600 IU. As a result of evidence of widespread vitamin D deficiency, prominent nutritional scientists are calling on Americans to increase their vitamin D intake to 1,000 IU per day and higher. Life Extension recommends that healthy adults supplement each day with at least 2,000 IU of vitamin D. Elderly adults may benefit from higher doses such as 5,000 IU daily up to 10,000 IU daily. The objective of taking a vitamin D supplement is to achieve an optimal 25-hydroxy vitamin D blood level of 50 ng/mL (and higher). Vitamin D in the amount of 2,000 IU is contained in the multinutrient Life Extension Mix and the multivitamin Two-Per-Day Tablets. A vitamin D blood test (available online or by calling the Life Extension Blood Lab at 1-800-208-3444), can help you determine the additional amount of vitamin D you may need to supplement to achieve an optimal level. Some individuals (such as those weighing more than 180 pounds) may require higher potencies of vitamin D. When combined with 1,000-3,000 IU obtained from multinutrient formulas, this 7,000 IU vitamin D3 softgel should enable these individuals to attain 25-hydroxyvitamin D blood levels above the desired range of 50 ng/mL. Life Extension has upgraded its vitamin D capsules to a small, easy to swallow softgel form that does not include allergen ingredients or vegetable stearate.

Americans have rightly been told to avoid table salt for decades. When iodized table salt is reduced, people can unknowingly lower their iodine intake to suboptimal levels. Analyses from the National Health and Nutrition Examination Survey (NHANES) show that urinary iodine levels have plummeted since the 1970s. Iodine is a health-promoting trace element essential for life. Its primary biological role lies in the production of the thyroid hormones triiodothyronine (T3) and thyroxine (T4).1 T4 and T3 contain four and three atoms of iodine per molecule, respectively. The thyroid gland actively absorbs iodide from the blood to make and release these hormones into the blood. Iodine is found abundantly in sea vegetables and plants. In areas where no marine foods are eaten, people have lower iodine levels.2 For this reason, US commercial salt manufacturers have added iodine to their product since the 1920s, in order to deliver this key ingredient to your diet. However, we now know the dangers associated with eating too much table salt, resurrecting the dilemma of where to get healthy sources of iodine. Ironically, health-conscious people are often most likely to develop low iodine levels.3 One reason is that athletes and people engaged in heavy physical effort deplete their natural stores of this trace mineral through perspiration, increasing their need for it. Vegetarians also have substantially greater likelihood of low levels of iodine than carnivorous people, since foods of plant origin are less rich in iodine than animal-derived foods. One study demonstrated iodine deficiency in 25% of vegetarians and 80% of vegans.4 The good news is that you can avoid iodized table salt without sacrificing the health benefits of iodine. Sea-Iodine is a low-cost proprietary formula that health conscious individuals can take each day to support optimal iodine levels. Using standardized extracts harvested from a blend of marine algae, Sea-Iodine brings you the health of the sea while avoiding the well known dangers of excessive salt intake. The purified extracts found in Sea-Iodine come from the pristine waters of Iceland and Nova Scotia, providing over 667% of the Recommended Daily Value of natural iodine. For those members who would like the convenience and economy of taking vitamin D and Sea-Iodine in just one capsule, Life Extension offers Vitamin D3 with Sea-Iodine. As a result of startling evidence of a widespread vitamin D deficiency, prominent nutritional scientists are calling on Americans to increase their vitamin D intake to 1000 IU per day and higher. Life Extension recommends that healthy adults supplement each day with at least 1000 IU of vitamin D. Older adults may benefit from doses such as 2000 IU daily, and even up to 5000 IU daily.

An avalanche of favorable studies has resulted in record numbers of Americans supplementing with vitamin D. Since it is virtually impossible to obtain adequate vitamin D from food sources, supplementation with 5,000-10,000 IU daily is required by many aging individuals. Overlooked by almost everyone (except Life Extension members) is the critical importance of vitamin K. If one is concerned enough about their health to take higher dose vitamin D, it seems absurd to miss out on the benefits of vitamin K. For instance, vitamin D facilitates calcium absorption into the bloodstream and thus plays an important role in maintaining bone density. Less recognized is the need for vitamin K to transport calcium from the bloodstream into the bone. Vitamin K is also required by calcium-regulating proteins in the arteries.1-5 Together these two vitamins help maintain youthful calcium skeletal distribution while promoting vascular health. Vitamin K can be found in small amounts in the diet, but obtaining the desired higher potencies requires supplementation. Many Life Extension members obtain optimal potencies of long-acting vitamin K in the Super Booster or Super K formulations. An increasing number of new members, however, are asking for high-potency vitamin D-but are not taking any supplemental vitamin K. To directly address this problem, Life Extension has put together a formula called Vitamins D and K with Sea-Iodine. Like vitamins D and K, few Americans obtain optimal amounts of iodine. As people seek to limit their salt intake, this deficit is exacerbated since iodized salt is the principal source of this mineral in many diets. We expect the issue of iodine insufficiency to receive more media attention as new studies uncover the problems this creates. Sea-Iodine is included in this formula to provide iodine without the harmful effects of sodium.

Aging individuals frequently encounter a weakening of the bladder and its sphincter muscle that controls the release of urine. Laboratory and human clinical studies demonstrate that ingestion of water-soluble pumpkin seed extract can significantly improve the structural support of the bladder and the function of the sphincter muscle. The data supporting the value of water-soluble pumpkin seed extract is particularly strong in studies performed in women . A clinical study of aging men also demonstrated positive results. The pumpkin seed has a long history of use in helping to maintain healthy bladder function. Japanese scientists have patented a method to obtain the water-soluble constituents of the pumpkin seed, which are absorbed far more efficiently into the bloodstream. These water-soluble pumpkin seed extracts appear to be the active constituents to help with the urinary discomforts endured by so many maturing women and men. For those who are taking other soy supplements or are allergic to soy, this version of Water-Soluble Pumpkin Seed Extract does not contain soy isoflavones.

Aging individuals frequently encounter a weakening of the bladder and its sphincter muscle that controls the release of urine. Laboratory and human clinical studies demonstrate that ingestion of water-soluble pumpkin seed extract (with soy isoflavones) can significantly improve the structural support of the bladder and the function of the sphincter muscle. The data supporting the value of water-soluble pumpkin seed extract (with soy isoflavones) is particularly strong in studies performed in women. A clinical study of aging men also demonstrated positive results. The pumpkin seed has a long history of use in helping to maintain healthy bladder function. Japanese scientists have patented a method to obtain the water-soluble constituents of the pumpkin seed, which are absorbed far more efficiently into the bloodstream. These water-soluble pumpkin seed extracts appear to be the active constituents to help with the urinary discomforts endured by so many maturing women and men. Clinical studies on women and men have used capsules containing 262 mg of water-soluble pumpkin seed extract and 50 mg of soy isoflavones taken two times each day. The results from human studies show the maximum benefits occurring after six to eight weeks of continued use. Based on remarkable and consistent clinical results, Life Extension is making the identical Japanese formula used in the human studies available to its members. For those who are taking other soy supplements or are allergic to soy, Water-Soluble Pumpkin Seed Extract is also available without soy.

Scientists have known for years that certain biological components of whey protein (including lactoferrin, beta-lactoglobulin, alpha-lactalbumin, glycomacropeptide, and immunoglobulins) have a beneficial impact on the immune system. Life Extension offers a specially designed whey protein isolate, using proprietary production methodology, that has been shown to support healthy immune function, protect against free radical attack, and help maintain lean muscle mass. Using a low temperature microfiltration technique, it is possible to produce a high-quality, 98% undenatured whey protein isolate that acts as a powerful immune stimulant and retains all the important sub-fractions, such as lactoferrin, a strong antioxidant with immune-stimulating properties. Whey protein contains a high concentration of branched-chain amino acids (BCAAs) leucine, isoleucine and valine, which play an important role in maintaining healthy muscle function is rich in sulfur-containing amino acids cysteine and methionine, which support a healthy immune response through intracellular conversion to glutathione provides potent antioxidant activity supports healthy cardiovascular function by maintaining healthy blood pressure and lipid levels that are already within a normal range promotes protein synthesis and muscle growth

Scientists have known for years that certain biological components of whey protein (including lactoferrin, beta-lactoglobulin, alpha-lactalbumin, glycomacropeptide, and immunoglobulins) have a beneficial impact on the immune system. Life Extension offers a specially designed whey protein isolate, using proprietary production methodology, that has been shown to support healthy immune function, protect against free radical attack, and help maintain lean muscle mass. Using a cross flow microfiltration technique, it is possible to produce a high-quality, 98% undenatured whey protein isolate that acts as an immune stimulant and retains all the important subfractions, such as lactoferrin, a strong antioxidant with immune-stimulating properties. Whey protein contains a high concentration of branched-chain amino acids (BCAAs) leucine, isoleucine and valine, which play an important role in maintaining healthy muscle function is rich in sulfur-containing amino acids cysteine and methionine, which support a healthy immune response through intracellular conversion to glutathione provides potent antioxidant activity supports healthy cardiovascular function by maintaining healthy blood pressure and lipid levels that are already within a normal range promotes protein synthesis and muscle growth

Findings from published scientific literature indicate that resveratrol may be the most effective plant extract for maintaining optimal health and promoting longevity. Research funded by the Life Extension Foundation showed that a combination of low-dose (20 mg) resveratrol plus grapeseed extract mimicked many of the favorable gene expression changes seen in calorie-restricted animals. Life Extension?s Whole Grape Extract has been formulated to provide high levels of standardized proanthocyanidins found in grape seed and skins.Grapeseed extract helps to maintain healthy platelet function and other aspects of platelet responses, and protects the central nervous system from reactive oxygen species. These proanthocyanidins and flavonoids are rapidly absorbed and distributed throughout the body, helping to eliminate free radicals while supporting healthy collagen. This is of particular importance in protecting the underlying supporting structure of the skin. Unlike competitive products that contain only proanthocyanidins, this blend also provides standardized trans -resveratrol and a whole red wine polyphenol extract.

Zinc is a mineral that stimulates the activity of approximately 300 enzymes, which are substances that promote biochemical reactions in your body. These reactions are essential for the formation of superoxide dismutase, one of the body?s most important free radical scavengers. Zinc also promotes immune function, taste sensitivity, protein and DNA synthesis, insulin production, reproductive organ development and sperm motility. Zinc also supports normal growth and development during pregnancy, childhood, and adolescence. Maintaining adequate levels of zinc is equally important to aging adults. As people grow older, their immune function declines, partly due to the decreasing size and function of the thymus gland. Evidence suggests that zinc may help to maintain healthy function of the thymus gland in elderly people. Scientists have also found evidence that a zinc deficiency in elderly adults may contribute to impaired immune function with aging, or immunosenescence. These findings suggest that zinc plays a critical role in supporting healthy immune function with age. Zinc Lozenges provide premium-grade zinc as gluconate, oxide, and aspartate plus the antioxidant vitamin C in a pleasant orange-flavored tablet.