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5-lipoxygenase (5-LOX) is a member of the lipoxy-genase family of enzymes. It transforms fatty acids into leukotrienes. Excess levels of the enzyme 5-LOX sets in motion inflammatory responses that have been linked to common degenerative effects in aging individuals. Normal aging results in higher-than-desired levels of 5-LOX. The typical American diet adds to the danger. Foods rich in omega-6 fatty acids like red meat, poultry, eggs and dairy products, along with high-glycemic carbohy­drates, trigger overproduction of arachidonic acid. In response to high levels of arachidonic acid, the body produces the 5-LOX enzyme. 5-LOX breaks down arachidonic acid to pro-inflam­matory compounds like leukotriene B4,14 a molecule that mediates attacks to joints, arterial walls, and other tissues. 5-LOX itself facilitates undesirable cell division changes. The good news is that an extract of the Indian plant Boswellia serrata has been shown to neutralize 5-LOX. Used for centuries to help with inflammatory issues, boswellia acts as a natural 5-LOX inhibitor, intervening at the cellular level to block its unwanted effects. Confirmatory data reveal that a compound contained in boswellia called AKBA (3-O-acetyl-11-keto-ß-boswellic acid)17,18 is the key to its beneficial action. The problem is that boswellia is poorly absorbed into the blood. For this reason, a patent-pending, standardized form of boswellia called AprèsFlex is being introduced. AprèsFlex absorbs into the blood 52% more than previously available boswellia extracts. Each 100 mg vegetarian capsule of 5-LOX Inhibitor with AprèsFlex is standardized to provide 20% of active AKBA from boswellia. Most people need only one capsule a day. It should be noted that although Life Extension?s previous 5-LOXIN formulation contained at least a 30% concentration of AKBA, the new AprèsFlex formula delivers more AKBA into the bloodstream, offering greater efficacy at a 20% concentration. One capsule of 5-LOX Inhibitor with AprèsFlex supplies the same amount of AprèsFlex as four vegetarian capsules of the new ArthroMax with Theaflavins & AprèsFlex.

7-Keto DHEA is a natural metabolite of DHEA that has been shown to safely increase thermogenesis, improve fat loss and help maintain healthy body weight when combined with a diet and exercise program. A clinical study indicated that 7-Keto DHEA increases the resting metabolic rate of overweight adults. 7-Keto DHEA may improve memory retention. Antioxidants are added based on the effect 7-Keto has in boosting mitochondrial oxidation.

7-Keto DHEA is a natural metabolite of DHEA that has been shown to safely increase thermogenesis, improve fat loss and help maintain healthy body weight when combined with a diet and exercise program. A clinical study indicated that 7-Keto DHEA increases the resting metabolic rate of overweight adults. 7-Keto DHEA may improve memory retention.

A major cause of aging is a reduction in the energy-producing components of the cell, resulting in reduced cellular metabolic activity, and the accumulation of cellular debris. L-carnitine helps maintain cellular energy metabolism by assisting in the transport of fatty acids from the cytosol into the mitochondria within the cell, where fats are oxidized to produce the cellular energy (adenosine triphosphate or ATP). Acetyl-L-carnitine is the acetylated ester of the amino acid L-carnitine. Acetyl-L-carnitine is an endogenous mitochondrial membrane compound that helps maintain mitochondrial bioenergetics and lowers the increased oxidative stress associated with aging. Acetyl-L-carnitine and L-carnitine are absorbed into the bloodstream efficiently. Both are effective at carrying long-chain fatty acids across the membrane into the mitochondria where they are burned for energy production and utilized efficiently by the cells. Acetyl-L-carnitine also guards against oxidative damage. Amyloid-beta peptide is a principal component of plaques and is thought to be a contributor to the aging process. Acetyl-L-carnitine exerts protective effects against such neurotoxicity and oxidative stress. Acetyl-L-carnitine (ALC) easily crosses the blood-brain barrier and may have potential in exerting unique neuroprotective, neuromodulatory and neurotrophic properties. ALC may support youthful memory function, improve mitochondrial structure and function, inhibit age-related oxidative damage, and restore the activity of key enzymes.

A major cause of aging is a reduction in the energy-producing components of the cell, resulting in reduced cellular metabolic activity, and the accumulation of cellular debris. L-carnitine helps maintain cellular energy metabolism by assisting in the transport of fatty acids from the cytosol into the mitochondria within the cell, where fats are oxidized to produce the cellular energy (adenosine triphosphate or ATP). Acetyl-L-carnitine is the acetylated ester of the amino acid L-carnitine. Acetyl-L-carnitine is an endogenous mitochondrial membrane compound that helps maintain mitochondrial bioenergetics and lowers the increased oxidative stress associated with aging. Acetyl-L-carnitine and L-carnitine are absorbed into the bloodstream efficiently. Both are effective at carrying long-chain fatty acids across the membrane into the mitochondria where they are burned for energy production and utilized efficiently by the cells. Acetyl-L-carnitine also guards against oxidative damage. Amyloid-beta peptide is a principal component of plaques and is thought to be a contributor to the aging process. Acetyl-L-carnitine exerts protective effects against such neurotoxicity and oxidative stress. In addition to supporting cellular energy metabolism, acetyl-L-carnitine arginate, which is a patented form of carnitine, also promotes optimal brain health.

When properly supported, the mechanism known as homeostasis enables the body to maintain its normal balance during stress, helping us to remain energized and focused. Increasingly overwhelmed by stress, however, our bodies seldom get a chance to restore our natural equilibrium. The result is that an estimated 75-90% of visits to primary care physicians are now related to the effects of stress. Even more alarming is a recently published study linking stress with shorter telomeres (the caps on the ends of chromosomes), which is associated with accelerated aging. Inhibiting the Pathways of Stress Stress disrupts multiple biochemical pathways, including cortisol production, the hypothalamus-pituitary-adrenal (HPA) axis, proinflammatory enzyme production and neurotransmitter production. A preclinical study has shown that stress also inhibits neural plasticity (the growth of new connections between neurons in the brain). Fortunately, Life Extension has created a state-of-the-art formulation of botanical adaptogens, shown to modulate a broad range of factors to help relieve the effects of stress. Adrenal Energy Formula combines four known stress-modulating extracts?Holy basil, cordyceps, Bacopa, and ashwagandha?each scientifically validated to support homeostasis, even on the most stressful days. Each of these extracts modulates a different set of stress related changes in the body?s chemistry. Combined, they may complement each other to provide complete adaptogenic stress defense. For those who are seeking protection from the damaging effects of stress, Adrenal Energy Formula is a broad-spectrum, potent, and safe formulation for maintaining healthy energy and vitality! Adrenal Energy Formula modulates stress and supports energy and balance.

When properly supported, the mechanism known as homeostasis enables the body to maintain its normal balance during stress, helping us to remain energized and focused. Increasingly overwhelmed by stress, however, our bodies seldom get a chance to restore our natural equilibrium. The result is that an estimated 75-90% of visits to primary care physicians are now related to the effects of stress. Even more alarming is a recently published study linking stress with shorter telomeres (the caps on the ends of chromosomes), which is associated with accelerated aging. Inhibiting the Pathways of Stress Stress disrupts multiple biochemical pathways, including cortisol production, the hypothalamus-pituitary-adrenal (HPA) axis, proinflammatory enzyme production and neurotransmitter production. A preclinical study has shown that stress also inhibits neural plasticity (the growth of new connections between neurons in the brain). Fortunately, Life Extension has created a state-of-the-art formulation of botanical adaptogens, shown to modulate a broad range of factors to help relieve the effects of stress. Adrenal Energy Formula combines four known stress-modulating extracts Holy basil, cordyceps, Bacopa, and ashwagandha each scientifically validated to support homeostasis, even on the most stressful days. Each of these extracts modulates a different set of stress related changes in the body?s chemistry. Combined, they may complement each other to provide complete adaptogenic stress defense. For those who are seeking protection from the effects of stress, Adrenal Energy Formula is a broad-spectrum, potent, and safe formulation for maintaining healthy energy and vitality! Adrenal Energy Formula modulates stress and supports energy and balance.

AdipoStat targets the mechanisms by which fat-storing cells or adipocytes become bloated and metabolically dysfunctional ? leading to excess fat accumulations in the belly and throughout your body. AdipoStat targets adipocyte (fat cell) creation. It impedes adipocyte growth (adipogenesis). And induces fat in adipocytes to break down (lipolysis). After careful scientific analysis of numerous plant extracts, researchers identified the two species included in AdipoStat that target adipocytes: Sphaeranthus indicus flower and the mangosteen fruit ( Garcinia mangostana ). Optimal results were shown in studies when these two plant extracts were combined. AdipoStat's performance in clinical studies indicates it can safely deliver impressive results. In a key study, 30 adults with difficulty maintaining healthy body weight ingested 800 mg per day of AdipoStat while following a 2,000-calorie-per-day diet and were asked to walk just 30 minutes five days a week. A group of equal size was given a placebo. After just eight weeks, the AdipoStat group: Lost 4.05 inches of harmful belly fat (2.0 times the placebo group). Experienced a 2.05 drop in body mass index (BMI) (3.9 times over placebo). Shed 11.4 pounds of total body weight (3.7 times over placebo). And these improvements began to emerge after just 14 days. After eight weeks, the AdipoStat group saw a noticeable drop in waist-to-hip ratio , indicating they experienced fat loss in the abdominal area , where excess fat mass is associated with serious health issues. They also exhibited favorably elevated levels of a hormone called adiponectin . Adiponectin sends command signals that determine how big your fat cells get, how much they break down (lipolysis), and how often they are produced (adipogenesis). A second human clinical trial yielded similar results, confirming AdipoStat's beneficial effects. Advanced Anti-Adipocyte Formula with AdipoStat also includes Integra-Lean African Mango Irvingia ? which operates via additional mechanisms to combat surplus fat storage, including inhibition of glycerol-3-phosphate dehydrogenase , an enzyme involved in the conversion of glucose and triglycerides into adipocyte fat storage.

Safely managing blood lipid levels can be a challenge for people as they get older. Yet an increasing number of doctors recognize the critical need to protect the arterial wall against low-density lipoprotein (LDL) oxidation and inflammatory insults. For those who want to maintain healthful levels of lipids in the blood, Advanced Lipid Control contains two powerful nutrients that help protect key aspects of cardiovascular function. This special formula supports healthy cholesterol levels already within normal range and safeguards vascular and heart health while providing excellent antioxidant protection. Theaflavin Extracts From Black Tea A staple beverage in many cultures for millennia, black tea contains theaflavins, beneficial flavonoids found naturally in its dried leaves. Advanced Lipid Control contains theaflavins, which scientists have discovered provide multiple benefits for arterial health. As well as supporting healthy cholesterol levels already within normal range, theaflavins have been shown in human studies to protect against LDL oxidation and favorably affect endothelial function , thus helping to maintain a healthy circulation. Scientists have also found that black tea flavo-noids possess strong antioxidant properties, which can help mitigate oxidative damage to cells and tissues from free radicals. In addition, theaflavins have been found to be helpful in regulating key inflammatory mediators in the body, thus helping to preserve endothelial integrity. Coronary-Protective Effects of Ancient Indian Berry Another ingredient in Advanced Lipid Control is AmlaMax , a patented extract of Indian gooseberry. It contains a diverse blend of phenolic compounds that have been clinically shown to safely help maintain healthy levels of all three key blood lipids - LDL , high-density lipoprotein (HDL), and triglycerides - as well as markers of inflammation such as C-reactive protein . Studies have also shown that this plant extract helps to induce rapid and significant improvement in endothelial function.

A woman?s loss of sexual vitality is related to a number of key factors, including suboptimal levels of sex hormones, neurotransmitters, and nitric oxide; and increased levels of pro-inflammatory cytokines and monoamine oxidase. Fortunately, Life Extension has created a state-of-the-art formulation of natural botanical extracts shown to modulate these underlying mechanisms. Advanced Natural Sex for Women introduces a unique phyto blend that targets and supports the mechanisms that promote healthy sexual function and libido. This formula includes Cordyceps, a mushroom extract that modulates the levels of sex hormones and promotes their downstream flow, boosts mitochondrial energy and sex interest by increasing adenosine triphosphate (ATP) production, supports vaginal lubrication and sexual function by promoting nitric oxide, and inhibits pro-inflammatory cytokines that can dampen sexual desire. In placebo-controlled studies, scientists documented that Cordyceps enhanced sexual function and desire in 86% of women in 40 days! Advanced Natural Sex for Women also contains the plant root extract Maca (Lepidium meyenii). Cultivated for over 2,000 years, Maca has now been shown to modulate levels and flow of sex hormones, support adrenal function, and promote libido and sexual pleasure by helping to optimize brain neurotransmitters and monoamine oxidase (MAO) levels. Women who took Maca scored over 35% better than placebo subjects on a standard sexual function and libido scale after just 6 weeks! Menopausal transition is considered the most difficult time for a woman to remain sexually active. In addition to the hot flashes and fatigue, vaginal dryness and loss of libido often interfere with sexual function. Advanced Natural Sex for Women 50+ contains Cordyceps and Maca plus three herbal root extracts (Phlomis umbrosa, Cyanchum wilfordii, Angelica gigas) used for over 400 years in Korea to help inhibit symptoms of menopause. Scientists found that when these three natural botanicals are uniquely blended then hot water extracted, they balance estrogenic activity in just those target tissues specifically related to menopausal symptoms. In a double-blind, placebo-controlled study, this special formulation (EstroG-100) helped inhibit menopausal symptoms by 62% in just 12 weeks!

Advanced Oral Hygiene is a new oral probiotic that provides the beneficial bacteria that can help block harmful bacteria that first develop in the mouth. This sophisticated oral probiotic therapy allows the healthy and naturally occurring organisms found in the body to out-compete the harmful bacteria. Advanced Oral Hygiene contains BLIS K12 and Bacillus coagulans, a unique blend of two oral probiotics. BLIS K12 (Streptococcus salivarius) and Bacillus coagulans (GanedenBC30) organisms naturally survive in human tissue, maximizing their health-promoting potential and providing help with the regulation of inflammation and cell destruction caused by germs that originate in the mouth to promote oral health. Regular use of Advanced Oral Hygiene could make a significant impact in protecting oral health, which in turn can strengthen the immune system, ease inflammation, and help the body maintain good health. Advanced Oral Hygiene can help modulate the body's inflammatory response, making these "good" microorganisms found in the BLIS K12 and GanedenBC30 strain the ideal candidates for easing inflammatory conditions in the body. In combination with a rigorous oral hygiene regimen, Advanced Oral Hygiene provides the body with beneficial bacteria to naturally help protect the immune system and help block bacteria from colonizing throughout the body.

Consuming alcoholic beverages results in the generation of free radicals. People who drink a lot of alcohol often suffer because of massive free radical-induced cellular damage. Alcohol-induced free radical assault can wreak short term havoc throughout the body, and these same damaging free radicals are associated with accelerated aging. Reactive oxygen species (ROS) have been associated with acute ethanol-induced liver damage. A study published in the journal Artery confirmed a specific toxic metabolite of alcohol (acetaldehyde) and identified an antidote (N-acetyl-L-cysteine): "All known pathways of ethanol metabolism result in the production of acetaldehyde, a highly reactive compound. N-acetyl-L-cysteine (NAC), an analogue of the dietary amino acid cysteine, binds acetaldehyde, thus blocking its damaging effect on physiological proteins." NAC is a glutathione precursor and direct antioxidant. Co-administration of NAC helps to inhibit acute ethanol-induced liver damage via counteracting ethanol-induced oxidative stress. NAC also attenuates the progression of the abnormal retention of lipids within liver cells by decreasing development of oxidative stress and subsequent increases in TNF-alpha. Thus, when people are exposed to a known toxic substance such as alcohol, it makes perfect sense to take a proven antidote - namely, antioxidants. Anti-Alcohol Antioxidants with HepatoProtection Complex is an improved formula containing additional antioxidants designed to suppress free radicals, neutralize toxic alcohol metabolites such as acetaldehyde, and support healthy liver function. In addition to vitamin B1, vitamin C, N-acetyl-L-cysteine and benfotiamine, this formula's HepatoProtection Complex provides therapeutic doses of these novel antioxidants: Chlorophyllin - an agent that protects the body from oxidative stress Leucoselect grapeseed extract, silymarin (from milk thistle), and trans -resveratrol - three hepatoprotective agents that aid in reducing compounds from potentially xenobiotics and protecting cells from free radical-induced oxidative stress Picroliv Picrorhiza kurroa root extract - contains antioxidant kutkin that scavenges alcohol-induced excess free radicals and stimulates regeneration of cells (hepatocytes) Taking the proper supplements before and after drinking can substantially protect liver cells from the free radical damaging effects of alcohol consumption.

The benefits of plant polyphenols are well known to health enthusiasts. These natural plant constituents block oxidative damage that leads to inflammation and accelerated biological aging of tissues. Recent studies by three separate laboratories have concluded that polyphenols extracted from apples extend life span in laboratory models by up to 12%.97 Apples and especially their skin, are rich in an array of polyphenols. One particular major bioactive polyphenol, phloridzin, found in the skin of many apple species, has been shown to act as a powerful agent against glycation and other destructive processes in the body. Phloridzin also regulates cell-to-cell signaling98 and supports healthy glucose levels in those already within normal range by inhibiting the glucose-6-phosphatase enzyme. Apple polyphenols can slow triglyceride absorption from the intestine by blocking pancreatic lipase, an enzyme specifically required to break down triglyceride fats. Additional research has shown that apple polyphenols can increase the protective antioxidant molecule, paraoxonase by as much as 23% thereby inhibiting lipid peroxidation and inflammatory factors. v Along with phloridzin, apples contain chlorogenic acid which supports healthy glucose levels in those already within normal range by inhibiting the glucose-6-phosphatase enzyme,99,100 and by increasing some cellular mechanisms that are stimulated by insulin in liver cells. AppleWise Polyphenol Extract is extracted from the highest quality organically grown apples.

Joint stiffness and discomfort is also a consequence of aging. With advancing age, there?s an increase in certain destructive cytokines (immune-modulating agents) that contribute to joint health conditions. Tumor necrosis factor (TNF-alpha) is one such agent. These pro-inflammatory agents have been implicated in a host of age-related problems including issues related to joints. Blocking the actions of pro-inflammatory cytokines is crucial for joint health. In addition to protecting joints from damaging free radicals, replacing naturally occurring joint-supporting nutrients like glucosamine and chondroitin is also important. Life Extension's Arthro-Immune Joint Support combines two clinically proven plant extracts into one powerful formula to help ease inflammation. Andrographis paniculata has received acclaim for its beneficial effect on inflammation. A Chilean study involved 60 adults who took either 150 mg andrographis extract daily or a placebo. Those taking the extract showed dramatic improvement of several outcomes, including fewer numbers of tender and/or swollen joints . For joints that remained tender and/or swollen, the intensity was lessened. Arthro-Immune Joint Support contains PARACTIN Andrographis extract , which has demonstrated its efficacy in easing inflammation in human clinical, in vivo and in vitro studies. Curcumin is a compound that is universally recognized for its impressive antioxidant and fluid-regulating properties. In an as-yet-unpublished double-blind clinical trial, an enhanced absorbing curcumin was shown to have a beneficial effect on inflammation. Arthro-Immune Joint Support also contains BCM-95 Bio-Curcumin , which is considered the gold standard curcumin, with bioavailability far superior to that of most curcumin extracts. Life Extension?s Arthro-Immune Joint Support provides scientifically validated plant extracts that have been shown to have significant salutary effects on joint health. Just one capsule a day provides a potent serving of PARACTIN and BCM-95 Bio-Curcumin.

As you grow older, age-related stiffness and discomfort in the joints becomes a fact of life. Activities once routine become a challenge as limited mobility hampers your every move. You now have a more potent option to provide broad-spectrum support for aging joints. ArthroMax Advanced with UC-II and AprèsFlex is a multi-nutrient formula based on the very latest data on natural support for joint health. This ArthroMax formula provides more joint support with two innovative, clinically validated ingredients: AprèsFlex and UC-II. AprèsFlex represents a quantum leap forward in the delivery of boswellia to aging joints. Long prized for its ability to help inhibit inflammatory factors, boswellia is especially effective at inhibiting the 5-LOX (5-lipoxygenase) enzyme. Excess activity of 5-LOX results in the accumulation of leukotriene B4, a pro-inflammatory compound that affects aging joints. Boswellia has been shown to bind directly to the 5-LOX enzyme, preventing it from facilitating production of pro-inflammatory leukotrienes. AprèsFlex boswellia absorbs into the blood 52% better than previously available forms of boswellia, for superior effectiveness. In addition to AprèsFlex, this ArthroMax formulation contains a standardized chicken cartilage called UC-II. Data shows it supports immune health, joint comfort and ease of motion in aging individuals.