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Melatonin is released from the pineal gland, reaching its peak at night to help maintain cell health throughout the body. Secretion of melatonin declines significantly with age as the pineal gland becomes calcified. Jet lag, shift work, and poor vision can disrupt melatonin cycles. Melatonin keeps our circadian cycle in tune. Not only does this hormone work to maintain cell health, it appears to regulate a system of self-repair and regeneration. As melatonin diminishes with age, our biological functions are impaired. Melatonin also has strong antioxidant properties. It directly scavenges both hydroxyl and peroxyl free radicals, and it does so more effectively than most other antioxidants. It also greatly potentiates the efficiency of other endogenous and exogenous antioxidants. Melatonin is especially important for protecting cellular DNA against peroxynitrite damage by inhibiting peroxynitrite free radical reactions. Some research has found that melatonin increases the speed of falling asleep and adds to the quality of sleep in about 60% of people who use it. Natural Sleep Melatonin provides a total of 5 mg of melatonin in addition to sleep-enhancing cofactors.

It?s hard to find a natural antidote to today?s overstressed world. The encouraging news is that lemon balm ( Melissa officinalis ), a perennial herb in the mint family native to the Mediterranean region, has been clinically proven to help promote sleep and relaxation. What?s more, lemon balm produces these calming effects while also enhancing memory and attention! Cyracos lemon balm extract is prepared from special lemon balm chosen for its high concentrations of hydroxycinnamic and rosmarinic acids. These active lemon balm constituents appear to enhance mood by modulating specific nicotinic and muscarinic receptors in the cerebral cortex of the brain. Aside from relieving everyday stress and sleep problems, this plant extract may also offer smokers relief from the mental stress of quitting, aid in leveling mood swings, and help reduce the emotional hunger associated with dieting (or following a calorie restriction regimen for anti-aging purposes). Relaxation-Promoting Effects of L-Theanine The Japanese have long known that L-theanine , an amino acid derived from green tea, is a natural relaxant that diminishes stress, without drowsiness, impaired thought, or other side effects. L-theanine produces calming effects in the brain in ways that have been compared to meditation, massage, and aromatherapy. L-theanine induces relaxation without causing drowsiness. In fact, studies show that L-theanine enhances the brain?s ability to concentrate, learn, and remember. L-theanine increases GABA (gamma-aminobutyric acid), an inhibitory neurotransmitter that not only induces relaxation but also produces a sense of well-being. L-theanine may normalize levels of dopamine, a critical brain hormone that is depleted by various stress factors. A Host of Health-Enhancing Benefits Research shows that L-theanine has numerous health-enhancing effects, including promoting healthy cognitive function. In studies of neurons in cell culture, L-theanine reversed glutamate- or other neurotoxicant-induced neurotoxicity, a major cause of normal brain aging. Based on an enormous amount of published data showing the multiple beneficial effects of lemon balm extract and L-theanine, Life Extension has combined these potent but safe nutrients into a formula called Natural Stress Relief . Note that the amount of L-theanine in this product is double that of most L-theanine standalone supplements. The reason for this potency increase is reports of greater benefit when at least 200 mg of L-theanine is taken. Beware of Imitations : The L-theanine used in Natural Stress Relief is Suntheanine, the only pure form of L-theanine protected by 40 internationally recognized patents and scientifically proven in clinical studies to be safe and efficacious. Independent laboratory analysis has verified that certain other products on the market claiming to contain ?L-theanine? are only half L-theanine, the other half being a different form of theanine known as ?D-theanine? which has not been scienti

Life extension's pure natural vitamin E provides only the better utilized natural vitamin E.

Half of the older people in the developed world are magnesium deficient. Don?t be one of them! Magnesium is needed for more than 300 biochemical reactions in the body. In addition to support for cardiovascular and bone health, energy metabolism and mood, researchers are now focusing intensely on magnesium?s benefits for cognitive function. Unfortunately, it is very hard for your body to maintain optimal levels of magnesium in the brain. This problem is of special concern for maturing individuals, as magnesium deficiency increases over time. Most commercially available magnesium supplements are not readily absorbed into the nervous system. To overcome this obstacle, you can supplement with an innovative form of magnesium called Neuro-Mag, shown to specifically target the aging brain and nervous system. In pre-clinical models, L-threonate contained in Neuro-Mag boosted magnesium levels in spinal fluid by an impressive 15% compared to no increase with conventional magnesium. Even more compelling, animal models revealed improvements of 18% for short-term memory and 100% for long-term memory using the Neuro-Mag form of magnesium. The suggested daily dose of three Neuro-Mag Magnesium L-Threonate capsules provides 2,000 mg of magnesium L-threonate. While this supplies a modest 144 mg of elemental magnesium, its superior absorption into the bloodstream and nervous system make it a preferred supplemental choice. This highly absorbable brain health-supporting magnesium is also available in a good tasting powder mix called Neuro-Mag Magnesium L-Threonate Powder with Calcium and Vitamin D3. In addition to its appealing lemon flavor, the one-scoop-per-day serving size supplies the same 144 mg of elemental magnesium plus 500 mg of calcium (as calcium lactate gluconate a highly soluble form of calcium) and 1,000 IU of vitamin D3.

Half of the older people in the developed world are magnesium deficient. Don?t be one of them! Magnesium is needed for more than 300 biochemical reactions in the body. In addition to support for cardiovascular and bone health, energy metabolism and mood, researchers are now focusing intensely on magnesium?s benefits for cognitive function. Unfortunately, it is very hard for your body to maintain optimal levels of magnesium in the brain. This problem is of special concern for maturing individuals, as magnesium deficiency increases over time. Most commercially available magnesium supplements are not readily absorbed into the nervous system. To overcome this obstacle, you can supplement with an innovative form of magnesium called Neuro-Mag, shown to specifically target the aging brain and nervous system. In pre-clinical models, L-threonate contained in Neuro-Mag boosted magnesium levels in spinal fluid by an impressive 15% compared to no increase with conventional magnesium. Even more compelling, animal models revealed improvements of 18% for short-term memory and 100% for long-term memory using the Neuro-Mag form of magnesium.

Niacin is the only B vitamin that can be synthesized in the liver from the amino acid tryptophan - on average, 1 mg of niacin can be synthesized from the ingestion of 60 mg of tryptophan. In its coenzyme forms, niacin is crucial to energy transfer reactions, particularly the metabolism of glucose, fat, and alcohol. No-Flush Niacin contains a special form of niacin, inositol hexanicotinate, consisting of six molecules of niacin chemically linked to an inositol molecule. It is hydrolyzed in the body to free niacin and inositol, which is a very slow process. Its unique properties allow for true niacin activity without the characteristic niacin flush that is unacceptable to many people.

Research has shed additional light on the multi-faceted benefits of alkylglycerols standardized from shark liver oil. Alkylglycerols act as immune system boosting agents.As a natural bacteria fighter, alkylglycerols are able to support the helper T-cells, which are highly sensitized to the bacteria-infected macrophage, and thus the body is able to regulate the bacteria.As an antifungal, alkylglycerols are beneficial because they are known to increase production of certain cytokines. (The daily dose of one 1000-mg Shark Liver Oil softgel, containing 260 mg of alkylglycerol, taken for up to 30 days, has been shown to be a powerful antifungal.)This Norwegian Shark Liver Oil is processed from the livers of sharks found in the waters off the coast of Norway. Each softgel is standardized to provide 260 mg of alkylglycerols.

Many of the validated benefits of the Mediterranean diet derive from heart-healthy compounds contained in the olive fruit, including the polyphenols tyrosol and hydroxytyrosol. When it comes to olive?s power to support blood pressure already within a healthy range, research shows the bioactive compound oleuropein is primarily responsible. The problem is that optimal amounts of oleuropein are not found in the fruit. The highest concentrations of oleuropein are contained in the olive leaf a part of the plant that is neither readily available nor commonly consumed. Oleuropein normally degrades during standard food processing. For this reason, Life Extension introduces Olive Leaf Vascular Support. Olive Leaf Vascular Support consists of a patented, standardized oleuropein extract using a unique, gentle-processing technique. Researchers using 1,000 mg per day of this formulation in a double-blind, controlled clinical trial documented an average 11.5-point (mmHg) decline in systolic readings and 4.8-point drop in diastolic readings in just eight weeks. The suggested daily serving of two 500 mg vegetarian capsules of Olive Leaf Vascular Support supplies optimal concentrations of this proprietary, highly stable oleuropein, for maximum benefit.

For decades, companies have sent samples of liquid fish oil supplements to Life Extension that claimed to taste good. These were all rejected because they either tasted bad or had an unpleasant aftertaste. Finally a method has been developed to make a sugar-free liquid fish oil that tastes great, and has no unpleasant aftertaste. An abundance of scientific research suggests wide ranging health dividends from the omega-3 fatty acids found in fish oil. Unfortunately, the typical Western diet is still disproportionately high in the omega-6 family of fatty acids and low in healthy omega-3 fatty acids. For Life Extension members who want another way to obtain the rich benefits of fish oils, there is now pleasantly natural flavored, easy to use, liquid omega-3 fish oil. Decades of research and over 15,000 studies confirm the vital importance of the omega-3 fatty acids known as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). Life Extension members already know that the EPA and DHA found in fish oil provide substantial support for normal heart and brain health. But research has increasingly shown that the health-promoting effects of EPA and DHA may extend to an even larger range of benefits. Life Extension Omega-3 Highly Refined Fish Oil is a premium fish oil derived from sustainable small-species fish sources (anchovy, sardine and/or mackerel) harvested from the deep cold waters of Chile. Through careful molecular distillation and gentle processing, this fish oil is tested and found extremely low levels of environmental pollutants and safe for everyone in the family. These sensationally-flavored liquid fish oils are available in natural lemon or piña colada flavors.

For decades, companies have sent samples of liquid fish oil supplements to Life Extension that claimed to taste good. These were all rejected because they either tasted bad or had an unpleasant aftertaste. Finally a method has been developed to make a sugar-free liquid fish oil that tastes great, and has no unpleasant aftertaste. An abundance of scientific research suggests wide ranging health dividends from the omega-3 fatty acids found in fish oil. Unfortunately, the typical Western diet is still disproportionately high in the omega-6 family of fatty acids and low in healthy omega-3 fatty acids. For Life Extension members who want another way to obtain the rich benefits of fish oils, there is now pleasantly natural flavored, easy to use, liquid omega-3 fish oil. Decades of research and over 15,000 studies confirm the vital importance of the omega-3 fatty acids known as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). Life Extension members already know that the EPA and DHA found in fish oil provide substantial support for normal heart and brain health. But research has increasingly shown that the health-promoting effects of EPA and DHA may extend to an even larger range of benefits. Life Extension Omega-3 Highly Refined Fish Oil is a premium fish oil derived from sustainable small-species fish sources (anchovy, sardine and/or mackerel) harvested from the deep cold waters of Chile. Through careful molecular distillation and gentle processing, this fish oil is tested and found extremely low levels of environmental pollutants and safe for everyone in the family. These sensationally-flavored liquid fish oils are available in natural lemon or piña colada flavors.

For many years, Life Extension members had to rely on commercial "one-a-day" supplements that provide very low potencies. When compared to conventional "one-a-day" products, Life Extension One-Per-Day contains up to 50 times more potency. One-Per-Day Tablets are an excellent choice for those seeking a premium-quality nutrient supplement that far surpasses off-the-shelf brands. Compared to Centrum Silver Adults 50+, the daily dose of Life Extension One-Per-Day Tablets provides about: 8 times more vitamin C 4 times more vitamin D 2 times more vitamin E 10 times more biotin 20 times more boron 4 times more selenium 25 times more vitamin B6 50 times more vitamin B1 12 times more vitamin B12 More than twice as much niacin, zinc, and many other nutrients. In response to member requests, the vitamin B12 in One-Per-Day tablets has been upgraded from cyanocobalamin to methylcobalamin. Additionally, the sodium selenate form of selenium has been changed to sodium selenite. There is a plethora of research demonstrating the beneficial effects of sodium selenite on overall health. Specifically, selenium helps promote healthy cell function. Methylcobalamin: Supports healthy cell growth and replication. Exerts neuroprotective effects. Acts as a cofactor for methionine synthesis in the conversion of homocysteine to methionine. Selenium: Helps mitigate oxidative damage to cells and tissues from free radicals. Promotes healthy thyroid function. It is a component of the enzyme that helps convert T4 (thyroxine) to T3 (triiodothyronine). Supports the body?s detoxification of heavy metals. Inhibits the activation of NF-kß.

Only Trace Minerals provides bioavailable forms of minerals in a convenient, low-cost supplement.

Scientists have discovered that the Indian herb ashwagandha (Withania somnifera) counters some of the oxidative damage generated by nervous tension. Ashwagandha has been the subject of animal studies and is believed to confer improvements in well-being and a healthy outlook in humans. In a large clinical trial, ashwagandha reduced levels of the hormone cortisol by up to 26% while maintaining already normal blood sugar levels and lipid profiles. Subjects who took the standardized ashwagandha extract reported improvements in energy, sleep and well-being, as well as diminished fatigue. Additional research suggests that ashwagandha confers neuroprotection by supporting the regeneration of axons and dendrites, nerve cell components that support brain and nervous system function. The suggested daily dose provides 250 mg of standardized, patented, non-stimulating Sensoril Ashwagandha Extract.

A major cause of aging is a reduction in the energy-producing components of the cell, resulting in reduced cellular metabolic activity, and the accumulation of cellular debris. L-carnitine helps maintain cellular energy metabolism by assisting in the transport of fatty acids from the cytosol into the mitochondria within the cell, where fats are oxidized to produce the cellular energy (adenosine triphosphate or ATP). Acetyl-L-carnitine is the acetylated ester of the amino acid L-carnitine. Acetyl-L-carnitine is an endogenous mitochondrial membrane compound that helps maintain mitochondrial bioenergetics and lowers the increased oxidative stress associated with aging. Acetyl-L-carnitine and L-carnitine are absorbed into the bloodstream efficiently. Both are effective at carrying long-chain fatty acids across the membrane into the mitochondria where they are burned for energy production and utilized efficiently by the cells. Acetyl-L-carnitine also guards against oxidative damage. Amyloid-beta peptide is a principal component of plaques and is thought to be a contributor to the aging process. Acetyl-L-carnitine exerts protective effects against such neurotoxicity and oxidative stress. Optimized Carnitine with GlycoCarn combines three advanced forms of carnitine in one single formula to help you optimize energy output: Acetyl-L-carnitine crosses the blood-brain barrier to combat oxidative stress and promote energy production in brain and central nervous system tissues. It also supports the release and synthesis of acetylcholine, enhances the release of dopamine from neurons and helps it bind to dopamine receptors. Acetyl-L-carnitine arginate dihydrochloride (ArginoCarn) is a patented form of acetyl-L-carnitine. Cell studies suggest that it promotes the growth of neurites that facilitate communication among nerve cells in the brain. GlycoCarn is a patented form of carnitine called glycine propionyl-L-carnitine that is molecularly bonded to glycine, one of the precursor amino acids to carnitine biosynthesis. This form offers such benefits as enhanced fatty acid metabolism, antioxidant activity and increased nitric oxide production. In addition, GlycoCarn promotes optimal blood flow and combats muscle fatigue by increasing energy and sparing glycogen stores. These optimized forms of carnitine help transport fatty acids right to the heart of your energy-producing mitochondria. And that boost in cellular function can help you produce cellular energy faster, for a quicker recovery after exercise and less muscle fatigue during exercise. It may also benefit your brain, heart, and central nervous system right along with your muscles.

Chromium, the metallic element once believed to be toxic, is now generally recognized as playing an important role in maintaining healthy blood sugar levels in those within normal levels when used as part of a healthy diet. This most recent version includes Crominex 3+ with standardized extract of Indian gooseberry and a proprietary form of the adaptogen shilajit for even greater support of heart health and healthy blood sugar levels already within normal range. This Crominex 3+ complex, with standardized extract of Indian gooseberry and a proprietary form of the adaptogen shilajit helps to support normal cellular glucose absorption, healthy endothelial function, healthy lipid and triglyceride levels, and normal cellular energy production.

The anatomy of the female urinary tract differs greatly from men, resulting in the need for additional nutritional support for women. A wealth of published studies indicates that cranberry polyphenols may help to support a healthy urinary tract. Of particular importance is the flavonoid content of the cranberry, including anthocyanins and proanthocyanidins . These natural compounds exert powerful antioxidant effects that can reduce oxidative stress. Recent clinical data suggest that the proanthocyanidins found only in cranberries also possess unique molecular features that specifically promote urinary system health. In a significant advance, Life Extension has identified a unique compound available overseas but little-known in the United States that provides a synergistic complement to the whole cranberry's phytonutrient profile. UTI Rose is derived from Hibiscus sabdariffa , a species native to Europe, Asia, and Africa. Scientific analysis has shown that this species' flower and calyx (the green floral envelope surrounding the blossom) are rich in active polyphenols, including flavonoids , sambubiosides , and proanthocyanidins . Of special importance is a flavonoid found in Hibiscus sabdariffa called gossypetin (3,5,7,8,3,' 4'-hexahydroxy flavone), which has been shown to provide support for urinary system health. Life Extension uses a unique, patented process in the manufacture of Optimized Cran-Max with UTI Rose . Each capsule supplies the complete phenolic profile of the whole cranberry plus hibiscus polyphenols in a standardized, highly absorbable, concentrated form. The suggested dose of one capsule twice daily delivers 500 mg of Cran-Max , to provide the anthocyanin equivalent of seven 8 oz. glasses of Ocean Spray Cranberry Juice Cocktail.

Folate is involved in neurotransmitter synthesis and critical enzymatic reactions throughout the body. By depleting excess homocysteine , folate benefits cardiovascular health and nervous system function . Optimal levels of folate are necessary for healthy cell division and protein synthesis and are especially important for the maintenance of a healthy GI tract. The systemic need for folate increases in certain states in which increased cell multiplication is needed. Chronic use of medications such as aspirin in therapeutic doses and antacids can interfere with the metabolism of folate. Those who take ordinary folate supplements, however, may not be experiencing its full spectrum of effects. This is because once ingested, not everyone converts folate to its biologically active form called 5-methyltetrahydrofolate (5-MTHF) . Research shows that in a large proportion of the population, genetic enzyme deficiencies prevent the conversion of folate to 5-MTHF , leaving many vulnerable to low blood folate levels (and higher than desired homocysteine). A more useful approach is to take the bioactive folate 5-MTHF directly, which has been declassified as a drug and is now available as a dietary supplement. 5-MTHF has been shown to dramatically raise red blood cell folate concentration, an indicator of folate status compared with folic acid supplementation. This bioactive folate is up to seven times more bioavailable than folic acid . This greater bioavailability is especially important in people who have a genetic enzyme deficiency since it requires no conversion to become metabolically active. People with elevated homocysteine levels have a greater risk of cognitive decline. Unlike folic acid, 5-MTHF is able to cross the blood-brain barrier, which is especially important for people with cognitive difficulties to enhance the synthesis of acetylcholine in the brain - the neurotransmitter associated with memory. Studies also show that the effectiveness of 5-MTHF can be further enhanced by co-supplementing with methylcobalamin (the active form of vitamin B12), vitamin B6, and riboflavin.

In recent years, scientific interest has intensified around fucoidan, a little-known molecule found primarily in edible seaweeds native to the Japanese diet. Nearly 900 published studies indicate its power to promote healthy immune function, cell-to-cell communication, and tissue maintenance. Many experts now believe fucoidan is one of the key nutrients responsible for the exceptionally long, healthy lives enjoyed in Okinawa, Japan which for decades boasted the world?s highest concentration of centenarians (individuals at least a century old). Maritech 926 fucoidan is sourced from hand-harvested, wild seaweed from the pristine ocean waters of Patagonia. A cutting-edge water extraction process ensures fucoidan?s delicate molecular structure is delivered intact, to provide the critical nutritional benefit of Undaria pinnatifida, the species of seaweed used in a majority of scientific fucoidan studies. A single vegetarian capsule of Optimized Fucoidan with Maritech 926 provides 88.5 mg of standardized Undaria pinnatifida extract, equaling the amount of fucoidan typically consumed daily in the traditional Japanese diet. Most people require just one capsule daily, but aging individuals seeking to enhance the benefit may choose to take two.

Garlic has been valued for centuries for its multi-faceted benefits. It has antioxidant action and can boost the level of natural glutathione, an important cellular detoxifier. The compounds allicin, oligosulfides, A. ursinum and A. sativum found in garlic support healthy platelet function.

Quercetin is a bioflavonoid that supports cellular health and function. In human cell culture studies, it has been shown to block the manufacture and release of inflammation-causing substances, which can help support a healthy immune response to the seasonally changing environment. It also helps promote a healthy cardiovascular system by preserving endothelial integrity and supporting healthy blood glucose levels for those already within normal range. Optimized Quercetin is a proprietary formulation that sets the ?gold standard? for high-quality quercetin derived from a food-source blend.

Life Extension has identified certain compounds that mimic calorie restriction?s ability to trigger youthful gene expression, the process by which genes transmit signals that slow certain aspects of aging. These compounds include trans -resveratrol (which researchers contend is the most active constituent), quercetin, plus certain compounds found in berries, including trans -pterostilbene and now fisetin. Resveratrol is a phytoalexin, a natural plant antibiotic which is produced by Vitis vinifera as a response to attack by molds. Because of the widespread use of pesticides in modern wine making, including the practice of copper sulfation, the level of resveratrol in modern wines has plummeted. Red wine contains resveratrol, but the quantity varies depending on where the grapes are grown, the time of harvest and other factors. In fact, usually only one to three mg of resveratrol per liter of red wine is currently found, even in the most robust red wines. After years of relentless research, a standardized resveratrol extract is now available as a dietary supplement. Research funded by the Life Extension Foundation showed that a combination of low-dose (20 mg) resveratrol plus grapeseed extract mimicked many of the favorable gene expression changes seen in calorie-restricted animals. Other studies, however, indicate that higher doses may be needed to obtain all of resveratrol?s positive benefits including promoting healthy insulin sensitivity, enhanced mitochondrial function, reduced expression of inflammatory factors, and protection against the toxic effects of a high-fat diet. Life Extension has evaluated published studies on resveratrol to establish the doses humans might need to take to duplicate the remarkable laboratory findings. The results of Life Extension?s analysis yield a wide range of potentially effective doses: from 20 to 250 mg a day and higher. The resveratrol potency you choose may be based on your current state of health and/or your desire to reach the upper limits of a healthy human life span. Pterostilbene, a stilbene compound from the same family as resveratrol, has been shown to work synergistically with resveratrol, to unlock one?s longevity genes ? thus conferring even greater anti-aging benefits. Fisetin, found in strawberries, has the power to ?switch on? cell signaling molecules that support youthful gene expression, DNA protection, and healthy cellular function. Fisetin also supports aging neurons in the presence of oxidative stress. And, most importantly, it works in synergy with resveratrol. Researchers have uncovered compelling evidence of fisetin?s ability to stabilize resveratrol by shielding it from metabolic breakdown, thus extending its beneficial effects! So naturally we added it, along with these other four calorie restriction mimics, to this most advanced resveratrol formulation.

Often find yourself snacking between meals? Can?t help reaching for that extra cookie? Having difficulty exercising portion control? Optimized Saffron with Satiereal may be just the answer you need.Satiereal is a clinically studied, proprietary extract of saffron...a spice that?s been prized since ancient Persia as a way to enhance mood and relieve stress.Previously available only in Europe, this standardized saffron extract provides support for healthy body weight by targeting some of the emotional factors that make you eat more when you?re trying to eat less.Just two 88.25 mg capsules of Optimized Saffron with Satiereal delivers the active constituents safranal and crocin, shown to modulate certain serotonergic receptors in the brain to support mood. In clinical studies, women taking Satiereal experienced:1.100% reduction in the desire to snack 2.50% fewer instances of eating between meals 3.Less hunger 4.Moderate weight loss 5.More energy 6.Better mood They experienced a greater sense of control over between-meal snacking, and a change in eating behavior, without that "jittery feeling" or other undesirable effects. They reported feeling better about themselves and better in general. This supplement should be taken in conjunction with a healthy diet and regular exercise program. Results may vary.