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Life Extension has gone to extraordinary lengths to identify those compounds that simulate calorie restriction's ability to trigger youthful gene expression ? the process by which genes transmit signals that slow certain aspects of aging. In 2003, we introduced standardized extract of resveratrol . In 2009, we introduced the "other" resveratrol, pterostilbene , a compound whose effects were found to work in synergy with resveratrol to activate your "longevity genes." We've brought together the five known calorie restriction mimetics ? trans -resveratrol, trans -pterostilbene, quercetin, grape seed polyphenols, and black tea extract in one, high potency formula. And to that we've now added a sixth to formulate CR Mimetic! This innovative formulation features the little-known flavonoid fisetin (which is most abundantly found in strawberries ). It is the sixth compound shown to simulate a youthful gene expression pattern similar to calorie restriction without significant dietary modification. Fisetin may also enhance the effects of resveratrol. Researchers have uncovered compelling evidence of fisetin's ability to stabilize resveratrol by shielding it from metabolic breakdown ? thus extending its effects. Fisetin has been shown to have the power to "switch on" powerful cell signaling molecules that support youthful gene expression, DNA protection, and healthy cellular function. Fisetin also supports aging neurons in the presence of oxidative stress. And each serving of CR Mimetic Longevity Formula contains fisetin in an amount equivalent to 2 cups of strawberries, helping to further emulate calorie restriction's favorable influence on your longevity genes. This unique formula provides cutting-edge broad-spectrum support for youthful gene expression from the most scientifically validated, natural sources.

The anatomy of the female urinary tract differs greatly from men, resulting in the need for additional nutritional support for women. A wealth of published studies indicates that cranberry polyphenols may help to support a healthy urinary tract. Cranberries have been known for decades to promote a healthy urinary tract. Clinical research demonstrates that cranberries' proanthocyanidins are powerful antioxidants that can reduce oxidative stress. A double-blind comparison study confirms that Cran-Max helps support a healthy urinary tract. Each Life Extension Cran-Max capsule contains 500 mg of cranberry concentrate to promote urinary tract health. Each Cran-Max capsule also contains: The synergistic, complete spectrum activity of the entire cranberry whole fruit A unique delivery system that protects its cranberry constituents from degradation Antioxidants Cran-Max contains concentrated cranberry made from the complete cranberry using a unique, patent-pending process. No sugar is added. Each capsule of Cran-Max contains powerful polyphenols, organic acids, and antioxidants, providing the same benefits as drinking cranberry juice cocktail, but without the calories. An advantage of Life Extension's Cran-Max is that it only requires once a day dosing!

Creatine is naturally produced in the human body from amino acids L-arginine, glycine, and L-methionine primarily in the kidney and liver and transported in the blood to help supply energy to all cells in the body. Creatine is metabolized into phosphocreatine, an important storage form used by the brain, heart, and skeletal muscles. In normal healthy individuals, muscle creatine is replenished at a rate of approximately two grams a day. Oral ingestion of creatine has been shown to suppress the body's natural production, an effect that has been shown to be reversed upon ceasing supplementation. Creatine exerts various effects upon entering the muscle. It is these effects that elicit improvements in exercise performance and may be responsible for the improvements of muscle function and energy metabolism seen under certain conditions. Several mechanisms have been proposed to explain the increased exercise performance seen after creatine intake: Optimizing energy metabolism by maintaining higher levels of the body's energy compound adenosine triphosphate or ATP. Increasing myofibrillar mRNA content and protein synthesis, and reducing amino acid oxidation and protein break-down. Increasing satellite cell and myonuclei number and activity in human skeletal muscle. Preventing tissue damage by stabilizing cellular membranes and maintaining reserves of ATP. One particularly interesting study found that the positive effects of creatine on strength and lean tissue in older adults continued after they stopped using creatine; at least for the duration of the study. The scientists concluded that "withdrawal from creatine had no effect on the rate of strength, endurance, and loss of lean tissue mass with twelve weeks of reduced-volume training." Along with a good diet and supplement regimen, regular exercise can greatly reduce the incidence of developing many health conditions. Research has shown exercise is important for our bodies and our minds. For decades, it has been considered scientific fact that the brains of adult mammals had a fixed number of cells. This idea has been challenged by several studies that showed exercise nearly doubled the number of cells in the area of the brain involved with learning and memory, known as the hippocampus. This study was done on mice, but regeneration of the hippocampus has now been shown in adult birds and monkeys. One of the researchers speculated that "intense exercise in a natural environment may be associated with a need for increased navigation skills." The hippocampus is thought to be the control center for the learning processes involved with navigating and understanding our surroundings. Exercise is as essential for our minds as it is for our bodies! The addition of creatine supplementation to an active lifestyle can provide added benefit to the health of the brain. One study found that creatine was very effective at reducing damage to brain tissue after injury. The researchers found that " ? administration of c

People suffering from cardiac and other debilitating health problems often exhibit severely depleted cellular energy in heart and muscle tissue, which can greatly impair normal daily functions. The primary source of energy for all cellular processes is a molecule known as ATP (adenosine triphosphate). Healthy, active cells constantly replenish their supply of ATP to produce vital cellular energy. However, under conditions of stress, injury, or aging, critical body tissues such as heart and skeletal muscles cannot produce ATP quickly enough to perform optimally. D-ribose, a carbohydrate molecule found in every living organism, facilitates the production of ATP. In studies of healthy athletes as well as those who have suffered injury to the heart muscle, supplying fatigued muscle cells with D-ribose quickly restored ATP levels to normal. By helping to rapidly refill depleted energy stores, D-ribose may be especially beneficial for people coping with cardiac and other problems marked by impaired cellular energy production. D-Ribose Tablets and D-Ribose Powder can help speed energy recovery, increase energy reserves and maintain healthy energy levels in heart and muscle tissue.